Rhabdomyolysis and myoglobinuric renal failure following cardioversion and CPR for acute MI.

A Study on the Effect of Cimetidine on Myoglobinuric Acute Kidney Injury in Male Rats

Introduction: Rhabdomyolysis-induced myoglobinuric acute renal failure accounts for about 10-40% of all cases of acute renal failure (ARF). Iron and Cytochrome P450 are involved in the pathogenesis of myoglobinuric ARF. The Aim of this Study: To explore the effect of cimetidine as a potent cytochrome P450 inhibitor on myoglobinuric ARF in rat. Methods: Twenty four rats were divided into 3 group...

A Study on the Effect of L-Carnitine on Myoglobinuric Acute Kidney Injury in Male Rats

Background: Rhabdomyolysis is frequently observed in patients admitted to the ICU. Rhabdomyolysis-induced myoglobinuric acute renal failure is one of the most common causes of death in this condition. Free radicals and nitric oxide are involved in the pathogenesis of myoglobinuric ARF. Aim of the Study: To study the effect of L-carnitine as an antioxidant on mARF in rats. Methods: Twenty four r...

Myoglobinuric acute renal failure following cardioversion in a boxfish poisoning patient.

Renal Replacement Therapy in Acute Kidney Failure due to Rhabdomyolysis

Rhabdomyolysis is a syndrome caused by skeletal muscle cells destruction which can occur for many reasons, including prolonged immobilization. The main complication of the syndrome is the development of acute renal failure. Rhabdomyolysis and myoglobinuria are responsible for approximately 5% of all causes of acute renal failure in the USA. The cause of rhabdomyolysis is often multifactorial, a...

Amphetamine-induced myoglobinuric acute renal failure.

A 36-year-old man was admitted because of sopor and dark urine after intravenous amphetamine injection. He subsequently developed myoglobinuria and acute renal failure. Serum myoglobin value was remarkably elevated to 83,000 ng/ml, and urine myoglobin was 400,000 ng/ml. Renal biopsy revealed tubular degeneration and tubular obstruction with myoglobin casts by immunofluorescence examination. Amp...